2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W727373
    2-(Cyclopropyl(methyl)amino)-5-phenyloxazol-4(5H)-one 14461-92-8
    2-(Cyclopropyl(methyl)amino)-5-phenyloxazol-4(5H)-one is structurally similar to known stimulants.
    2-(Cyclopropyl(methyl)amino)-5-phenyloxazol-4(5H)-one
  • HY-W727525
    Donepezil-d7 1215071-00-3
    Donepezil-d7 (E2020-d7 (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.
    Donepezil-d7
  • HY-W728110
    5-MeO-pyr-T 3949-14-2
    5-MeO-pyr-T (5-Methoxy pyrrolidinyltryptamine) is a 5-HT1AR agonist, with Kis of 0.577 and 373 μM for 5-HT1AR and 5-HT2AR respectively. 5-MeO-pyr-T inhibits 5-HT uptake and elicits 5-HT release. 5-MeO-pyr-T induces hypolocomotion.
    5-MeO-pyr-T
  • HY-W728631
    2-(3-Fluorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride 2657761-24-3
    2-(3-Fluorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride is an arylcyclohexylamine.
    2-(3-Fluorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride
  • HY-W728879
    5-Aminoisotonitazene 2732926-25-7
    5-Aminoisotonitazene is a urinary metabolite of the analgesic, synthetic opioid agent isotonitazene.
    5-Aminoisotonitazene
  • HY-W735205
    (1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride 675126-09-7
    (1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride is a metabolite of the selective serotonin reuptake inhibitor (SSRI) Sertraline (HY-B0176A).
    (1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride
  • HY-W739056
    SAMe-1,4-Butanedisulfonate-d3
    SAMe-1,4-Butanedisulfonate-d3 is the deuterium labeled SAMe-1,4-Butanedisulfonate (HY-W105505). SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders
    SAMe-1,4-Butanedisulfonate-d3
  • HY-W739944
    Ambroxol-d5 1246818-80-3
    Ambroxol-d5 (NA-872-d5) is deuterium labeled Ambroxol. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
    Ambroxol-d5
  • HY-W740014
    N-Desmethyl Zolmitriptan 139264-35-0
    N-Desmethyl Zolmitriptan (183C91; DZT) is the active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist Zolmitriptan (HY-B0229). N-Desmethyl Zolmitriptan (183C91; DZT) is an agonist of 5-HT1B receptors and induces constriction in isolated human cerebral arteries (EC50=100 nM).
    N-Desmethyl Zolmitriptan
  • HY-W740628
    Nicorandil pyridine oxide 107833-98-7
    Nicorandil pyridine oxide is a metabolite of the sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (SUR2B/Kir6.2) activator and nitric oxide donor Nicorandil.
    Nicorandil pyridine oxide
  • HY-W740630
    8-Hydroxy mirtazapine 102335-57-9
    8-Hydroxy mirtazapine is a metabolite of the antidepressant Mirtazapine (HY-B0352). 8-Hydroxy mirtazapine is formed from mMirtazapine by the cytochrome P450 (CYP) isoform CYP2D6.
    8-Hydroxy mirtazapine
  • HY-W741165
    N-Demethyl methylone hydrochloride 38061-37-9
    N-Demethyl methylone hydrochloride s a cathinone.
    N-Demethyl methylone hydrochloride
  • HY-W741575
    Iloperidone carboxylic acid 475110-48-6
    Iloperidone carboxylic acid (P95-12113) is the metabolite of Iloperidone (HY-17410). Iloperidone carboxylic acid exhibits good affinity for 5-HT2A receptor with pKi of 8.15, and moderate affinity for adrenergic receptor α1/α2B/α2C.
    Iloperidone carboxylic acid
  • HY-W741886
    5-Methoxy-N-isopropyl tryptamine 109921-55-3
    5-Methoxy-N-isopropyl tryptamine is a tryptamine. 5-Methoxy-N-isopropyl tryptamine is a metabolite of 5-methoxy DiPT.
    5-Methoxy-N-isopropyl tryptamine
  • HY-W743021
    4-Methyl-α-ethyltryptamine 28289-30-7
    4-Methyl-α-ethyltryptamine is a homolog of α-Ethyltryptamine. α-Ethyltryptamine alters monoamine release and re-uptake in the brain.
    4-Methyl-α-ethyltryptamine
  • HY-W743300
    2,3-MDA hydrochloride 86029-48-3
    2,3-MDA hydrochloride is a structural isomer of 3,4-Methylenedioxyamphetamine (MDA) which differs only in the placement of the methyledioxy group.
    2,3-MDA hydrochloride
  • HY-W743525
    (±)-p-Fluoro pseudoephedrine hydrochloride 7799-73-7
    (±)-p-Fluoro pseudoephedrine hydrochloride is a metabolite of 4-Fluoromethcathinone. 4-Fluoromethcathinone is a cathinone.
    (±)-p-Fluoro pseudoephedrine hydrochloride
  • HY-W743870
    5α-Dihydrodeoxycorticosterone 298-36-2
    5α-Dihydrodeoxycorticosterone is an intermediate product of Deoxycorticosterone (HY-113414) catalyzed by 5α-reductase. 5α-Dihydrodeoxycorticosteron levels associated with depression.
    5α-Dihydrodeoxycorticosterone
  • HY-W744643
    Butylphthalide-d9 2251692-52-9
    Butylphthalide-d9 (3-n-Butylphthalide-d9) is deuterium labeled Butylphthalide. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.
    Butylphthalide-d9
  • HY-W744953
    Carbimazole-d3
    Carbimazole-d3 is deuterium labeled Carbimazole. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.
    Carbimazole-d3
Cat. No. Product Name / Synonyms Application Reactivity